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A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis.

Hiroshi KasamatsuTakenao ChinoTakumi HasegawaNatsuko UtsunomiyaAkira UtsunomiyaMasami YamadaNoritaka OyamaMinoru Hasegawa
Published in: Arthritis research & therapy (2023)
Our results prove that calpains can be a novel therapeutic target for skin and lung fibrosis in SSc, considering its inhibitor ALLN.
Keyphrases
  • soft tissue
  • wound healing
  • high glucose
  • diabetic rats
  • liver fibrosis
  • mouse model
  • pulmonary fibrosis
  • fluorescent probe
  • oxidative stress
  • endothelial cells
  • single molecule
  • stress induced