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CIC break-apart fluorescence in-situ hybridization misses a subset of CIC-DUX4 sarcomas: a clinicopathological and molecular study.

Akihiko YoshidaYasuhito AraiEisuke KobayashiKan YonemoriKoichi OguraNatsuko HamaWakako MukaiToru MotoiAkira KawaiTatsuhiro ShibataNobuyoshi Hiraoka
Published in: Histopathology (2017)
CIC break-apart FISH assays missed a significant minority of CIC-DUX4 sarcomas, and full awareness of typical morphology and judicious immunohistochemical work-ups, including analyses of ETV4 and WT1, should complement diagnostic assessment.
Keyphrases
  • high grade
  • single molecule
  • acute lymphoblastic leukemia
  • high throughput