Gene therapy in Aβ-induced cell and mouse models of Alzheimer's disease through compensating defective mitochondrial complex I function.

Hongzhi LiZhuo ChenYuqi ShenTing XiongAndong ChenLixia ChenYifan YeQingyou JiangYaxi ZhangJun SunLuxi Shen

Published in: Journal of translational medicine (2024)

Compensating mitochondrial complex I function with yeast NDI1 is effective for gene therapy in Aβ-induced AD cell and mouse models. The results of this study offer a novel strategy and approach for treating AD types characterized by complex I abnormalities.

Keyphrases

gene therapy
mouse model
oxidative stress
high glucose
single cell
diabetic rats
cell therapy
drug induced
stem cells
saccharomyces cerevisiae
cell wall