Transforming growth factor beta receptor II (TGFBR2) promoter region polymorphism in Brazilian breast cancer patients: association with susceptibility, clinicopathological features, and interaction with TGFB1 haplotypes.
Glauco Akelinghton Freire VitielloMarla Karine AmaranteBruna Karina Banin-HirataClodoaldo Zago CamposKaren Brajão de OliveiraRoberta Losi-GuembarovskiMaria Angelica Ehara WatanabePublished in: Breast cancer research and treatment (2019)
These results indicate that G-875A is a protective factor against BC, especially from luminal-A subtype, but may promote anaplasia in established tumors, consistent with TGFβ signaling roles in BC.