Diagnosis of verruciform acanthotic vulvar intra-epithelial neoplasia (vaVIN) using CK17, SOX2 and GATA3 immunohistochemistry.

Eleanor CookKoen K van de Vijver Carlos Parra-Herran

Published in: Histopathology (2024)

CK17, SOX2 and GATA3 can be useful in the diagnosis of vaVIN and its distinction from hyperplastic non-neoplastic vulvar lesions. Although CK17 has higher sensitivity, SOX2 and GATA3 are more specific, and the combination of all markers shows optimal diagnostic accuracy.

Keyphrases

transcription factor
protein kinase
stem cells
sentinel lymph node
high grade
early stage
radiation therapy
lymph node
neoadjuvant chemotherapy