Acoustic Enrichment of Heterogeneous Circulating Tumor Cells and Clusters from Metastatic Prostate Cancer Patients.
Cecilia MagnussonPer AugustssonEva Undvall AnandAndreas LenshofAndreas JosefssonKarin WelénAnders BjartellYvonne CederHans LiljaThomas LaurellPublished in: Analytical chemistry (2024)
Our preliminary data indicate that acoustophoresis provides excellent possibilities to detect and characterize CTC clusters as a putative marker of metastatic disease and outcomes. Moreover, acoustophoresis enables the sensitive label-free enrichment of cells with epithelial phenotypes in blood and offers opportunities to detect and characterize CTCs undergoing epithelial-to-mesenchymal transitioning and lineage plasticity.
Keyphrases
- circulating tumor cells
- prostate cancer
- label free
- end stage renal disease
- small cell lung cancer
- squamous cell carcinoma
- circulating tumor
- ejection fraction
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- stem cells
- radical prostatectomy
- bone marrow
- cell cycle arrest
- prognostic factors
- type diabetes
- electronic health record
- cell death
- skeletal muscle
- single cell
- big data
- endoplasmic reticulum stress
- cell proliferation
- deep learning
- artificial intelligence
- glycemic control