Interaction of a Jaundice Marker Molecule with a Redox-Modulatory Nano-Hybrid: A Combined Electrochemical and Spectroscopic Study toward the Development of a Theranostic Tool.
Susmita MondalNivedita PanRia GhoshArpan BeraDipanjan MukherjeeTuhin Kumar MajiAnirudddha AdhikariSangeeta GhoshChinmoy BhattacharyaSamir Kumar PalPublished in: ChemMedChem (2022)
This study explores a combined electrochemical and spectroscopic approach to investigate the degradation of bilirubin, a molecular marker of jaundice in humans using a biocompatible nanohybrid (citrate-functionalized Mn 3 O 4 nanohybrid; C-Mn 3 O 4 NH). The approach is aimed at the development of a facile theranostic tool for treatment, detection, and prognosis of jaundice. Linear sweep voltammetry (LSV) studies on bilirubin, C-Mn 3 O 4 NH, a model carrier protein, and its complex with bilirubin reveal the efficacy of the nanohybrid for both degradation and detection of bilirubin. Furthermore, spectroscopic studies depict that distal electron transfer to be the probable mechanism behind the observed bilirubin degradation in physiological milieu.
Keyphrases
- electron transfer
- room temperature
- molecular docking
- label free
- reduced graphene oxide
- gold nanoparticles
- ionic liquid
- photodynamic therapy
- molecularly imprinted
- metal organic framework
- gene expression
- minimally invasive
- fluorescence imaging
- small molecule
- mass spectrometry
- genome wide
- protein protein
- single molecule
- real time pcr
- transition metal
- perovskite solar cells
- abdominal pain
- neural network
- iron oxide