Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis.
Daniella M J CheangRoly J ArmstrongWasim M AkhtarTimothy J DonohoePublished in: Chemical communications (Cambridge, England) (2020)
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.