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4-Hydroxyhalcone effects on cisplatin-induced genotoxicity model.

Aref NazariMina MirianMahmoud AghaeiMehdi Aliomrani
Published in: Toxicology research (2021)
Our results demonstrated the antigenotoxic action of 4-HCH in CP-treated mice bone marrow cells for the first time in both concentrations of 10 and 40 mg/kg especially in the form of co-treatment. Further studies required clinical application of this compound in a combination of CP to attenuate the normal cells' genotoxicity side effects.
Keyphrases
  • induced apoptosis
  • bone marrow
  • cell cycle arrest
  • mesenchymal stem cells
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway
  • type diabetes
  • metabolic syndrome
  • newly diagnosed
  • pi k akt
  • combination therapy