Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis.
Rikke Holm Holm HansenJacob TalbotHelene Højsgaard ChowMalene Bredahl HansenSophie BuheltSebastian HerichNicholas SchwabMarie Nathalie Nickelsen HellemJoergen Erik NielsenFinn SellebjergMarina Rode von EssenPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
Our study indicates substantial changes in intrathecal Tfh dynamics, particularly in patients with RRMS, and suggests that the intrathecal inflammatory environment in patients with RRMS promotes recruitment of peripheral Tfh cells rather than the Tfh cells having an increased capacity to migrate to CNS.