Meta-analysis of microarray data to determine gene indicators involved in cisplatin resistance in non-small cell lung cancer.
Somayeh Hashemi SheikhshabaniParatoo ModarresSeyedeh Morvarid NeishabouriZeinab Amini-FarsaniLavin KhodaeeNasibeh ShayganZahra Amini-FarsaniMir Davood OmraniPublished in: Cancer reports (Hoboken, N.J.) (2024)
We identified several molecular factors that contribute to cisplatin resistance in NSCLC cell lines, involving genes and pathways that regulate gap junction communication, DNA damage repair, ROS balance, EMT induction, and stemness maintenance. These genes and pathways could be targets for future studies to overcome cisplatin resistance in NSCLC.
Keyphrases
- dna damage
- genome wide
- small cell lung cancer
- systematic review
- genome wide identification
- epithelial mesenchymal transition
- bioinformatics analysis
- stem cells
- oxidative stress
- case control
- advanced non small cell lung cancer
- cell death
- gene expression
- electronic health record
- copy number
- genome wide analysis
- meta analyses
- big data
- machine learning
- artificial intelligence
- single molecule