Sex Disparities in Outcomes Following Major Liver Surgery: New Powers of Estrogen?
Dominique L BirrerMichael LineckerVíctor López-LópezRoberto BrusadinÁlvaro Navarro-BarriosTim ReeseSahar ArbabzadahDeniz BalciMassimo MalagoMarcel A MachadoVictoria ArdilesOlivier SoubraneRoberto Hernandez-AlejandroEduardo de SantibañesKarl J OldhaferIrinel PopescuBostjan HumarPierre-Alain ClavienRicardo Robles-CamposPublished in: Annals of surgery (2022)
Poorer outcomes after major surgery in males and shorter ALPPS interstage intervals in females not necessarily suggest a superior regenerative capacity of female liver. The loss of interstage advantages in postmenopausal women and the mouse experiments point to estrogen as the driver behind these sex disparities. Estrogen's benefits call for an assessment in postmenopausal women, and perhaps men, undergoing major liver surgery.