Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species.

Namki ChoTanya T RansomJanet SigmundTrong TranRobert H CichewiczMichael GoetzJohn A A Beutler

Published in: Journal of natural products (2017)

Bioassay-guided fractionation of a colon cancer growth inhibitory extract of the fungus Paraconiothyrium sp. led to the isolation of eight new versiol derivatives (1, 3-8, 10) along with two known compounds. The structures were elucidated by interpretation of combined MS and 2D NMR spectroscopic data. Compounds 8, 9, and 10 showed cell growth inhibition against COLO205 and KM12 cells, and both 8 and 9 displayed selectivity in their inhibition of melanoma cell lines in the NCI 60 one-dose test. In addition, compound 8 and the crude Paraconiothyrium sp. extract showed potent dose-dependent inhibitory effects in the five-dose NCI 60 cell line assay.

Keyphrases

oxidative stress
induced apoptosis
anti inflammatory
high resolution
magnetic resonance
multiple sclerosis
mass spectrometry
molecular docking
ms ms
high throughput
machine learning
big data
endoplasmic reticulum stress
cell proliferation
signaling pathway
cell death
molecular dynamics simulations