Altered levels of salivary and plasma pain related markers in temporomandibular disorders.

Hajer JasimBijar GhafouriBjörn GerdleBritt Hedenberg-MagnussonMalin Ernberg

Published in: The journal of headache and pain (2020)

The higher levels of salivary and plasma glutamate in patients with TMD-myalgia compared to controls strengthens its importance in the pathophysiology of TMD-myalgia. However, the lack of correlation to pain levels question its role as a putative biomarker. Patients with TMD-myalgia further had lower levels of salivary NGF and BDNF, but higher plasma BDNF. These results and their correlations to psychological distress warrant further investigations.

Keyphrases

chronic pain
neuropathic pain
stress induced
spinal cord
depressive symptoms
spinal cord injury
growth factor
sleep quality