Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats.
Kandaswamy SelvakumarSenthamilselvan BavithraSekaran SuganyaFirdous Ahmad BhatGunasekaran KrishnamoorthyJagadeesan ArunakaranPublished in: Journal of biomarkers (2012)
Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.
Keyphrases
- high density
- red blood cell
- high glucose
- induced apoptosis
- diabetic rats
- cell cycle arrest
- drug induced
- stem cells
- blood pressure
- single cell
- metabolic syndrome
- endothelial cells
- small molecule
- combination therapy
- type diabetes
- cell therapy
- protein protein
- signaling pathway
- newly diagnosed
- insulin resistance
- bone marrow
- replacement therapy