The nucleotide composition of microbial genomes indicates differential patterns of selection on core and accessory genomes.
Jon BohlinVegard EldholmJohn H O PetterssonOla BrynildsrudLars SnipenPublished in: BMC genomics (2017)
The higher intragenic GC content and relative entropy, as well as the lower GC content variation, observed in the core genomes is most likely associated with selective constraints. It is unclear whether the positive association between GC content and relative entropy in the more mobile accessory genomes constitutes signatures of selection or selective neutral processes.