Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort.
Susan PetersKarin BrobergValentina GalloMichael LeviMaria KipplerPaolo VineisJan VeldinkLeonard van den BergLefkos MiddletonRuth C TravisManuela M BergmannDomenico PalliSara GrioniRosario TuminoAlexis ElbazTim VlaarFrancesca ManciniTilman KühnVerena KatzkeAntonio AgudoFernando GoñiJesús-Humberto GómezMiguel Rodríguez-BarrancoSusana MerinoAurelio BarricarteAntonia TrichopoulouMazda JenabElisabete WeiderpassRoel VermeulenPublished in: Annals of neurology (2020)
This is the first study to compare metal levels before disease onset, minimizing reverse causation. The observed associations suggest that cadmium, lead, and zinc may play a role in ALS etiology. Cadmium and lead possibly act as intermediates on the pathway from smoking to ALS. ANN NEUROL 20209999:n/a-n/a.