Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.
Husvinee SundaramurthiValentina TonelottoKieran WynneFiona O'ConnellEve O'ReillyMarcel Costa-GarcíaCsenger KovácsháziÁgnes KittelSimone MarconeAlfonso BlancoEva PallingerSzabolcs HambalkóJose Maria Piulats RodriguezPéter FerdinandyJacintha O'SullivanDavid MatallanasLasse D JensenZoltán GiriczBreandán N KennedyPublished in: Open research Europe (2023)
Ergolide is a novel, promising anti-proliferative agent for UM/MUM. Proteomic profiling of OMM2.5 cellular/EV lysates identified candidate pathways elucidating the action of ergolide and putative biomarkers of UM, that require further examination.