Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset.

Gregory C McDermottRitu GillStaci GagneSuzanne ByrneWeixing HuangJing CuiLauren PriscoAlessandra ZaccardelliLily MartinVanessa L KronzerMatthew MollMichael H ChoNancy ShadickPaul F DellaripaTracy DoyleJeffrey A Sparks

Published in: Rheumatology (Oxford, England) (2022)

The common MUC5B promoter variant was associated with RA-ILD onset earlier in the RA disease course and older age of RA onset. These findings suggest that the MUC5B promoter variant may impact RA-ILD risk early in the RA disease course, particularly in patients with older-onset RA.

Keyphrases

interstitial lung disease
rheumatoid arthritis
systemic sclerosis
disease activity
dna methylation
idiopathic pulmonary fibrosis
ankylosing spondylitis
gene expression
transcription factor
physical activity