Exposure to omentum adipose tissue conditioned medium from obese pregnant women promotes myometrial artery dysfunction.
Christina E HaywardElizabeth J CowleyColin P SibleyJenny E MyersMark WareingPublished in: The journal of obstetrics and gynaecology research (2017)
Omental adipose tissue from OB pregnant women produced altered concentrations of adipokines. Acute OB medium exposure induced MA dysfunction, an effect not mirrored by exposure to leptin. These data suggest that an aberrant endocrine environment created by increased central adiposity in OB pregnant women induces vascular endothelial dysregulation, which may predispose them to a poor pregnancy outcome.
Keyphrases
- pregnant women
- adipose tissue
- insulin resistance
- pregnancy outcomes
- high fat diet
- oxidative stress
- drug induced
- high glucose
- liver failure
- metabolic syndrome
- endothelial cells
- diabetic rats
- type diabetes
- respiratory failure
- electronic health record
- machine learning
- preterm birth
- obese patients
- weight gain
- bariatric surgery
- artificial intelligence
- extracorporeal membrane oxygenation
- mechanical ventilation