Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair.
Masanori SaitoStephanie N Moore-LotridgeS UppugantiSatoru EgawaT YoshiiJ P RobinetteSamuel L PoseyBreanne H Y GibsonH A ColeG D HawleyScott A GuelcherS B TannerJason R McCarthyJ S NymanJonathan G SchoeneckerPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2021)
There is a specific pharmacologic window following polytrauma that bisphosphonates can prevent the consequences of dysregulated biomineralization, yet not impair musculoskeletal regeneration.