Dynamics of IgM and IgG responses to the next generation of engineered Duffy binding protein II immunogen: Strain-specific and strain-transcending immune responses over a nine-year period.
Camila M P MedeirosEduardo U M MoreiraCamilla V PiresLetícia M TorresLuiz F F GuimarãesJéssica R S AlvesBárbara A S LimaCor J F FontesHelena L CostaCristiana F A BritoTais N SousaFrancis Babila NtumngiaJohn H AdamsFlora S KanoLuzia Helena CarvalhoPublished in: PloS one (2020)
The current study demonstrates that long-term exposure to low and unstable levels of P. vivax transmission led to a sustained DBPII-specific IgM response against variant-specific epitopes, while sustained IgG responses are skewed to conserved epitopes. Further studies should investigate on the role of a stable and persistent IgM antibody response in the immune response mediated by DBPII.