Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects.
Jeane de Souza NogueiraCíntia Barros Santos-RebouçasRafael Mina PiergiorgeAna Paula ValenteMarcos C Gama-AlmeidaTatiana El-BachaMaria Luiza Lopes MoreiraBruna Silva Baptista MarquesJessica Rodrigues de SiqueiraErika Martins de CarvalhoOrlando da Costa FerreiraLuís Cristóvão Moraes Sobrino PortoTatiana Kelly da Silva FidalgoGilson Costa Dos SantosPublished in: Journal of proteome research (2023)
The adsorbed vaccine SARS-CoV-2 (inactivated) produced by Sinovac (SV) was the first vaccine against COVID-19 to be used in Brazil. To understand the metabolic effects of SV in Brazilian subjects, NMR-based metabolomics was used, and the immune response was studied in Brazilian subjects. Forty adults without (group - , n = 23) and with previous COVID-19 infection (group + , n = 17) were followed-up for 90 days postcompletion of the vaccine regimen. After 90 days, our results showed that subjects had increased levels of lipoproteins, lipids, and N -acetylation of glycoproteins (NAG) as well as decreased levels of amino acids, lactate, citrate, and 3-hydroxypropionate. NAG and threonine were the highest correlated metabolites with N and S proteins, and neutralizing Ab levels. This study sheds light on the immunometabolism associated with the use of SV in Brazilian subjects from Rio de Janeiro and identifies potential metabolic markers associated with the immune status.