Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline.
Melina StarkSteffen WolfsgruberLuca KleineidamIngo FrommannSlawek AltensteinClaudia BartelsFrederic BrosseronKatharina BuergerLena BurowMichaela ButrynMichael EwersKlaus FliessbachTatjana GabelinWenzel GlanzDoreen GoerssDaria GrefNiels HansenMichael T HenekaPetra HindererEnise I IncesoyDaniel JanowitzIngo KilimannOkka KimmichChristoph LaskeMatthias H MunkMatthias BrendelOliver PetersLukas PreisJosef PrillerBoris-Stephan RauchmannAyda RostamzadehNina Roy-KluthCarolin SanzenbacherAnja SchneiderBjörn Hendrik SchottAnnika SpottkeEike Jakob SpruthStefan TeipelIna R VogtJens WiltfangEmrah DuzelFrank JessenMichael WagnerPublished in: Neurology (2023)
Our results suggest that MNPD are a risk factor for AD related clinical progression in cognitively normal patients seeking medical counseling due to SCD. As such, the assessment of MNPD could be useful for individual clinical prediction and for AD risk stratification in clinical trials. However, SCD remains a risk factor for future cognitive decline even in the absence of MNPD.
Keyphrases
- cognitive decline
- mild cognitive impairment
- clinical trial
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- traumatic brain injury
- prognostic factors
- peritoneal dialysis
- mental health
- physical activity
- smoking cessation
- current status
- hepatitis c virus
- patient reported
- antiretroviral therapy
- double blind