Login / Signup

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation.

Andrés FernándezElena QuintanaPatricia VelascoBelén Moreno-JimenezBelén de AndrésMaria Luisa GasparIsabel ListeMarçal VilarHelena MiraEva Cano
Published in: Journal of neuroinflammation (2021)
Our data validate the SAMP8 model to study age-associated neuroinflammatory events, but careful controls for age and strain are required. These animals show morphological changes in their bMyC cell repertoires associated to age, corresponding to an increase in the production of pro-inflammatory cytokines such as IL-1β, which predispose the brain to an enhanced inflammatory response after LPS-systemic challenge.
Keyphrases