Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation.
Andrés FernándezElena QuintanaPatricia VelascoBelén Moreno-JimenezBelén de AndrésMaria Luisa GasparIsabel ListeMarçal VilarHelena MiraEva CanoPublished in: Journal of neuroinflammation (2021)
Our data validate the SAMP8 model to study age-associated neuroinflammatory events, but careful controls for age and strain are required. These animals show morphological changes in their bMyC cell repertoires associated to age, corresponding to an increase in the production of pro-inflammatory cytokines such as IL-1β, which predispose the brain to an enhanced inflammatory response after LPS-systemic challenge.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- anti inflammatory
- traumatic brain injury
- single cell
- cell therapy
- electronic health record
- machine learning
- white matter
- multiple sclerosis
- metabolic syndrome
- type diabetes
- stem cells
- high fat diet induced
- cognitive impairment
- mesenchymal stem cells
- insulin resistance
- functional connectivity
- artificial intelligence