Interleukin-10 deficiency exacerbates inflammation-induced tau pathology.

Lea L WestonShanya JiangDevon ChisholmLauren L JantzieKiran Bhaskar

Published in: Journal of neuroinflammation (2021)

These data support that loss of IL-10 activates microglia, enhances IL-6, and leads to hyperphosphorylation of tau on AD-relevant epitopes in response to acute systemic inflammation.

Keyphrases

drug induced
cerebrospinal fluid
oxidative stress
liver failure
diabetic rats
high glucose
inflammatory response
electronic health record
respiratory failure
neuropathic pain
big data
aortic dissection
replacement therapy
machine learning
artificial intelligence
spinal cord injury
data analysis