A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.

Juhong WangFei ShaoYannan YangWei WangXueying YangRenda LiHong ChengSijin SunXiaoli FengYibo GaoJie HeZhimin Lu

Published in: Cancer communications (London, England) (2022)

These results revealed a critical non-metabolic function of HK2 in promotion of cancer cell stemness. Our findings provided new insights into the multifaceted roles of HK2 in tumor development.

Keyphrases

small cell lung cancer
stem cells
epithelial mesenchymal transition
high glucose
brain metastases
endothelial cells