Toxic anti-phage defense proteins inhibited by intragenic antitoxin proteins.

Aoshu ZhongXiaofang JiangAlison B HickmanKatherine KlierGabriella I C TeodoroFred DydaMichael T LaubGisela Storz

Published in: bioRxiv : the preprint server for biology (2023)

genes. Intriguingly, a sequence present in both long and short protein shows extensive variation in the number of four amino acid repeats. Consistent with a strong selection for the variation, we provide evidence that the Rpn proteins represent a phage defense system.

Keyphrases

amino acid
pseudomonas aeruginosa
gene expression
innate immune
cystic fibrosis
binding protein