Synergistic Chemo-Photothermal Antibacterial Effects of Polyelectrolyte-Functionalized Gold Nanomaterials.
Ruohao ZhangJie YuKun MaYufan MaZhuo WangPublished in: ACS applied bio materials (2020)
With the increasing threat of bacterial infection to human health, the development of different antimicrobial agents is essential. Therefore, based on the photothermal conversion properties of gold nanomaterials, the polyelectrolyte (PE)-coated gold nanorods (GNR@PE) and gold nanostars (GNS@PE) are designed and synthesized. Consequently, the chemo-photothermal synergistic antibacterial effect is achieved. GNR@PE effectively eliminates the high toxicity of cetyltrimethylammonium bromide (CTAB), and both GNR@PE and GNS@PE have good biocompatibility and stability. Because of the cation coating, GNR@PE and GNS@PE show high localized surface charge, which causes strong affinity to bacteria and destruction of bacterial cell walls and cell membranes. They have good chemical antibacterial effects, and the chemical antibacterial rates are above 50%. Under the irradiation of an 808 nm laser, for Gram-negative bacteria and Gram-positive bacteria, GNR@PE (50.00 μg/mL) and GNS@PE (55.00 μg/mL) can kill more than 99% of bacteria through chemo-photothermal effects. GNR@PE and GNS@PE can help eliminate inflammation caused by infection and promote wound healing in the mice model and have few side effects on the organs of mice.
Keyphrases
- photodynamic therapy
- cancer therapy
- silver nanoparticles
- drug delivery
- human health
- wound healing
- risk assessment
- oxidative stress
- staphylococcus aureus
- mesenchymal stem cells
- bone marrow
- climate change
- mass spectrometry
- cell therapy
- ionic liquid
- locally advanced
- high resolution
- insulin resistance
- molecularly imprinted