Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia.
Alessandro GalganiFrancesco LombardoNicola MartiniAndrea VergalloLuca BastianiHarald HampelHana HlavataFilippo BaldacciGloria TognoniDaniele De MarchiIrene GhicopulosSara De CoriFrancesca BiagioniCarla Letizia BuscetiRoberto CeravoloUbaldo BonuccelliDante ChiappinoGabriele SicilianoFrancesco FornaiNicola PaveseFilippo Sean GiorgiPublished in: European journal of neurology (2022)
Our findings highlight a potential role of LC-MRI for predicting clinical progression in Mild Cognitive Impairment and support the key role of LC degeneration in the Alzheimer clinical continuum.