Hypoxic storage of donor red cells preserves deformability after exposure to plasma from adults with sickle cell disease.

Matthew S KarafinJoshua J FieldAnton IlichLang LiBahjat F QaquishSergey S Shevkoplyas Tatsuro Yoshida

Published in: Transfusion (2022)

Hypoxic storage significantly influenced RBC deformability. Patient condition significantly influenced post-incubation hemolysis. Together, HRBCs in steady-state plasma maximized donor red cell ex vivo function and survival.

Keyphrases

induced apoptosis
red blood cell
cell cycle arrest
single cell
case report
cell therapy
endoplasmic reticulum stress
oxidative stress
stem cells
free survival
signaling pathway
mesenchymal stem cells