Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer.
Hyein JeongJaemoon KohSehui KimSeung Geun SongSoo Hyun LeeYoungjoo JeonChul-Hwan LeeBhumsuk KeamSe-Hoon LeeDoo Hyun ChungYoon Kyung JeonPublished in: British journal of cancer (2024)
Tumor cell-intrinsic PD-L1 function contributes to NSCLC progression by promoting EMT. EMT may predict an unfavorable outcome after ICI therapy in PD-L1-high NSCLC.