Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors.
Kwong-Kwok WongNicholas W BatemanChun Wai NgYvonne T M TsangCharlotte S SunJoseph CelestinoTri V NguyenAnais MalpicaR Tyler HillmanJianhua ZhangP Andrew FutrealChristine RojasKelly A ConradsBrian L HoodClifton L DalgardMatthew D WilkersonNeil T PhippenThomas P ConradsGeorge L MaxwellAnil K SoodDavid M GershensonPublished in: Journal of translational medicine (2022)
This is the first study to use whole-genome sequencing to detect somatic mutations in LGSOCs with matched normal tissues. We detected and validated novel mutations in DNM3, which were present in 3 of the 14 samples analyzed. Additionally, we identified novel indels, regions with CNVs, dysregulated mRNA, dysregulated proteins, and phosphosites that are more prevalent in short-term survivors. This integrated proteogenomic analysis can guide research into the pathogenesis and treatment of LGSOC.