High-fat diet-induced obesity worsens TH2 immune response and immunopathologic characteristics in murine model of eosinophilic oesophagitis.
Flávia Márcia de Castro E SilvaErick Esteves de OliveiraMarcilene Gomes Evangelista AmbrósioMarina Caçador AyupeViviane Passos de SouzaJacy GameiroDaniele Ribeiro de Lima ReisMarco Antonio MachadoGilson Costa MacedoJoerg MattesAna Paula FerreiraPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
Obesity aggravated the immune histopathological characteristics in the EoE experimental model, which was associated with the reduction in the regulatory profile, and the increased inflammatory cells influx, related to the TH 2 profile. Altogether, the data provide new knowledge about obesity as a risk factor, worsening EoE symptoms, and contribute for future treatment strategies for this specific profile.
Keyphrases
- high fat diet induced
- insulin resistance
- metabolic syndrome
- immune response
- weight loss
- type diabetes
- weight gain
- induced apoptosis
- adipose tissue
- risk factors
- skeletal muscle
- healthcare
- oxidative stress
- endoplasmic reticulum stress
- machine learning
- cell death
- sleep quality
- depressive symptoms
- electronic health record
- chronic rhinosinusitis