Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study.

Giorgia QuerinPeter BedeMohamed Mounir El MendiliMenghan LiMélanie Pélégrini-IssacDaisy RinaldiMartin CatalaDario SaracinoFrançois SalachasAgnes CamuzatVéronique Marchand-PauvertJulien Cohen-AdadOlivier ColliotIsabelle Le BerPierre-François Pradatnull null

Published in: Annals of neurology (2019)

Cervical SC imaging detects WM atrophy exclusively in C9+ subjects older than 40 years, and progressive CST FA reductions can be identified on 18-month follow-up. Cervical SC magnetic resonance imaging readily captures presymptomatic pathological changes and disease propagation in c9orf72-associated conditions. ANN NEUROL 2019;86:158-167.

Keyphrases

spinal cord
magnetic resonance imaging
high resolution
multiple sclerosis
spinal cord injury
physical activity
neuropathic pain
middle aged
community dwelling