The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype.

Aparna KareddulaDaniel J MedinaWhitney PetroskySonia DolfiIrina TereshchenkoKelly WaltonHana AvivEvita SadiminAlexandra L TabakinEric A SingerKim M Hirshfield

Published in: Therapeutic advances in urology (2021)

These data suggest that in erythroblast transformation specific (ETS) fusion-negative, phosphatase and tensin homolog (PTEN) wildtype PCa, deletion of CHD1 alters cell-cell and cell-matrix adhesion dynamics, suggesting an important role for CHD1 in the development and progression of PCa.

Keyphrases

prostate cancer
single cell
cell therapy
binding protein
cell proliferation
stem cells
transcription factor
staphylococcus aureus
pi k akt
deep learning
data analysis