Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic Resistance.

John Z MetcalfeElizabeth StreicherGrant TheronRebecca E ColmanChristopher AllenderDarrin LemmerRob WarrenDavid M Engelthaler

Published in: American journal of respiratory and critical care medicine (2017)

Cryptic minor variant mycobacterial subpopulations exist below the resolving capability of current drug susceptibility testing methodologies, and may explain an important proportion of false-negative resistance determinations.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
emergency department
drug induced