Association of Global DNA Methylation to Titanium and Peri-Implantitis: A Case-Control Study.

Diane M DaubertA E PozhitkovL M SafiotiG A Kotsakis

Published in: JDR clinical and translational research (2019)

These are the first human data to elucidate the epigenetic regulation of gene transcription via hypermethylation as a potential mechanism involved in peri-implantitis. Furthermore, they identify titanium dissolution products as a potential environmental factor associated with this hypermethylation, which provides cues for novel therapeutic targets for peri-implantitis.

Keyphrases

dna methylation
human health
genome wide
endothelial cells
gene expression
electronic health record
transcription factor
risk assessment
induced pluripotent stem cells
big data
climate change
machine learning
deep learning