Rh(III)-Catalyzed Tandem Bicyclization of 2-Arylimidazo[1,2-a]pyridines with Cyclic Enones for the Construction of Bridged Scaffolds.

An efficient Rh(III)-catalyzed bicyclization of 2-arylimidazo[1,2-a]pyridine with cyclic enones has been developed for the synthesis of bridged imidazopyridine derivatives in excellent yields up to 95%. The reaction proceeds through a sequential conjugate addition of ortho-C-H bond of aryl group followed by an intramolecular C3-alkylation of imidazopyridine ring in a highly regioselective manner.