Anti-inflammatory effects of α7-nicotinic ACh receptors are exerted through interactions with adenylyl cyclase-6.

Simeng ZhuShiqian HuangGuofang XiaJin WuYan ShenYing WangRennolds S OstromAilian DuChengxing ShenCongfeng Xu

Published in: British journal of pharmacology (2021)

The α7-nAChRs inhibit inflammation through activating adenylyl cyclase-6 and promoting degradation of TLR4. The use of α7-nAChR agonists may represent a novel therapeutic approach for treating COPD and possibly other inflammatory diseases.

Keyphrases

oxidative stress
chronic obstructive pulmonary disease
toll like receptor
inflammatory response
signaling pathway
lung function
immune response
nuclear factor
cystic fibrosis