Failure of mecA/mecC PCR Testing to Accurately Predict Oxacillin Resistance in a Patient with Staphylococcus aureus Infective Endocarditis.

Kyle A HessKirstin KoodaJoshua D Shirley Audrey N SchuetzOmar Abu SalehRyan W Stevens

Published in: Antimicrobial agents and chemotherapy (2023)

Genotypic testing for mecA / mecC is heavily relied upon for rapid optimization of antimicrobial therapy in infections due to Staphylococcus aureus. Little is known regarding optimal reporting and/or therapy for patients demonstrating lack of genotypic evidence of mecA or mecC but phenotypic oxacillin resistance. We report a case of a 77-year-old patient with S. aureus bloodstream infection and infective endocarditis with discordance between mecA/mecC genotypic results and phenotypic susceptibility testing.

Keyphrases

staphylococcus aureus
end stage renal disease
case report
ejection fraction
biofilm formation
chronic kidney disease
newly diagnosed
prognostic factors
escherichia coli
mesenchymal stem cells
multidrug resistant
cystic fibrosis
adverse drug
klebsiella pneumoniae
gram negative
cell therapy
replacement therapy