U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors.

Jianguo LiDeping YanXiaoyan LiuYe WangXin ZhaoYu ZhangCe Zhang

Published in: Neurological research (2018)

These findings suggest a novel mechanism by which the ERK1/2 signaling pathway affects the post-I/R apoptosis of CA1 pyramidal neurons, which will provide a therapeutic target for the treatment of stroke.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
endoplasmic reticulum stress
cell cycle arrest
epithelial mesenchymal transition
spinal cord
oxidative stress
atrial fibrillation
cerebral ischemia
cell death
protein kinase
combination therapy
temporal lobe epilepsy