Detection of DNA copy number alterations by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of single nucleotide polymorphisms.
Shengnan JinDan HuangWeijiang JinYourong WangHengrong ShaoLisha GongZhenni LuoZhengquan YangJu LuanDeyao XieChunming DingPublished in: Clinical chemistry and laboratory medicine (2022)
CNA detection by MALDI-TOF MS can be used for validating potentially interesting genomic regions identified from next generation sequencing, and for detecting CNAs in tumor tissues consisting of a mixture of neoplastic and normal cells.
Keyphrases
- copy number
- mitochondrial dna
- genome wide
- loop mediated isothermal amplification
- induced apoptosis
- dna methylation
- circulating tumor
- real time pcr
- mass spectrometry
- label free
- gene expression
- cell cycle arrest
- single molecule
- cell free
- cell death
- cell proliferation
- endoplasmic reticulum stress
- signaling pathway
- nucleic acid