HLA antibody repertoire in infants suggests selectivity in transplacental crossing.
Dana M SavulescuMichelle GroomeSusan C K MalfeldShabir MadhiAnthonet KoenStephanie JonesVania DuxburyKarine ScheuermaierDebbie De Assis RosaMelinda SuchardPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
Our findings raise the possibility of selection in transplacental crossing of HLA antibodies. As HLA antibodies may act as autoantibodies in the neonate, the mechanism of a selective transfer may give important insights into immune tolerance. Findings also suggest that infants start producing their own HLA antibodies in the first weeks of life, which, together with maternally derived antibodies may impact the infant's immune reaction to HLA proteins.
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