[18F]-florbetaben PET/CT is sensitive for cardiac AL amyloidosis.
Raffaella Cassano CassanoDario GenovesiGiuseppe VergaroAssuero GiorgettiAlberto AimoMaria Livia Del GiudiceSara GalimbertiMichele EmdinGabriele BudaPublished in: European journal of clinical investigation (2024)
Often differential diagnosis between AL and ATTR amyloidosis is difficult. Concerning ATTR, sensitive diagnostic tool, as diphosphonate scintigraphy, was validated, instead of no imaging approach is as accurate in AL. Cardiac ultrasound and circulating biomarkers may raise the clinical suspicion but biopsy remains the only option for diagnosis. We aimed to explore the sensitivity of 18F-Florbetaben PET respect to blood tests or periumbilical fat (POF), cardiac, bone marrow (BM) or other tissues biopsies in a cohort of 33 patients.
Keyphrases
- pet ct
- bone marrow
- left ventricular
- end stage renal disease
- positron emission tomography
- high resolution
- ultrasound guided
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- magnetic resonance imaging
- gene expression
- computed tomography
- mesenchymal stem cells
- adipose tissue
- multiple myeloma
- peritoneal dialysis
- heart failure
- patient reported outcomes