Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury.

Alvin TieuDuncan J StewartDamian ChwastekCasey LansdellDylan BurgerManoj M Lalu

Published in: Stem cell research & therapy (2023)

MSC-EVs exhibit maximal lung accumulation when administered during heightened inflammation at 24 h after ALI induction. This lung tropism suggests that MSC-EVs may serve as a practical rescue treatment for acute inflammatory respiratory conditions.

Keyphrases

bone marrow
oxidative stress
liver failure
lipopolysaccharide induced
stem cells
lps induced
heart rate
intensive care unit
combination therapy
respiratory tract
pet ct
extracorporeal membrane oxygenation
acute respiratory distress syndrome