Effect of amoxicillin-clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin-resistant Escherichia coli in dogs with uncomplicated acute diarrhea.
Melanie WernerJan S SuchodolskiReinhard K StraubingerGeorg WolfJoerg M SteinerJonathan A LidburyFelix NeuererKatrin HartmannStefan UntererPublished in: Journal of veterinary internal medicine (2020)
Our study suggests that treatment with amoxicillin-clavulanic acid confers no clinical benefit to dogs with AD, but predisposes the development of amoxicillin-resistant E. coli, which persist for as long as 3 weeks after treatment. These findings support international guideline recommendations that dogs with diarrhea should not be treated with antimicrobials unless there are signs of sepsis.
Keyphrases
- escherichia coli
- intensive care unit
- irritable bowel syndrome
- liver failure
- acute kidney injury
- clostridium difficile
- clinical practice
- staphylococcus aureus
- cystic fibrosis
- gestational age
- combination therapy
- septic shock
- multidrug resistant
- newly diagnosed
- replacement therapy
- smoking cessation
- mechanical ventilation