Serum IgG2 and tissue IgG2 plasma cell elevation in orbital IgG4-related disease (IgG4-RD): Potential use in IgG4-RD assessment.

Anita S Y ChanHardeep MudharSunny Yu ShenStephanie S LangMalee FernandoMaryam Hazly HilmyNaomi Jayne GuppyIan RennieLisa DunkleyIssam Al Jajeh

Published in: The British journal of ophthalmology (2017)

Significant elevations of serum IgG2 and tissue IgG2 plasma cells are present in orbital IgG4-RD in comparison with non-IgG4 orbital inflammation (idiopathic and autoimmune OID), suggesting that IgG2 may play a role in IgG4-RD. A serum IgG2 cut-off >5.3 g/L was found to be 80% sensitive and 91.7% specific for orbital IgG4-RD, with an accuracy of 0.90. Tissue IgG2 and IgG4 subclass reporting may provide additional insight regarding the 'IgG4-RD' pathogenesis.

Keyphrases

multiple sclerosis
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single cell