Synthesis and Study of Building Blocks with Dibenzo[ b,f ]oxepine: Potential Microtubule Inhibitors.

The synthesis of biphenylmethoxydibenzo[ b,f ]oxepine or photoswitchable fluorinated dibenzo[ b,f ]oxepine derivatives with one or three azo bonds, potential microtubule inhibitors, is described. Our studies provide a concise method for constructing derivatives containing the dibenzo[ b,f ]oxepine skeleton. An analysis of products was run using experimental and theoretical methods. Next, we evaluated the E / Z isomerization of azo -dibenzo[ b,f ]oxepine derivatives, which could be photochemically controlled using visible-wavelength light.