Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model.

Michael Nguyen-Truong Wenqiang LiuJune BoonBrad NelsonJeremiah EasleyEric MonnetZhijie Wang

Published in: Animal models and experimental medicine (2020)

In summary, the animal-specific, repeated PAC provided a robust approach to induce adult RVF, and this ovine model will offer a useful tool to study the progression and treatment of adult RVF that is translatable to human diseases.

Keyphrases

pulmonary artery
pulmonary hypertension
coronary artery
pulmonary arterial hypertension
endothelial cells
childhood cancer
mitral valve
heart failure
neuropathic pain
replacement therapy
congenital heart disease
atrial fibrillation